A protein older than blood circulation could transform cancer immunotherapy
Scientists at Nagoya University have discovered that the protein complement C3, when produced locally within tumor tissue, helps the immune system fight cancer. This mechanism prevents immunosuppressive cells from entering the tumor microenvironment, offering a potential new target for immunotherapy.
An immune molecule that appeared in evolution long before blood circulation may help improve cancer immunotherapy. Scientists at Nagoya University in Japan discovered that complement C3 can prevent immune-suppressing cells from building up inside tumors, but only when the protein is produced locally within the tumor. C3 traveling through the bloodstream did not influence how well treatment worked.
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