Early-Onset Colorectal Cancer Risk Factors Explored

MALE sex and Hispanic ethnicity increase early-onset colorectal cance r risk, while foreign maternal birthplace provides protection. In a large population-based nested case-control study from the California Linkage Study of Early-Onset Cancers, investigators evaluated statewide birth records matched with cancer registry data from 1988 through 2021. The investigation encompassed 1,221 individuals diagnosed with first primary early-onset colorectal cancer between ages 0 and 39 years, along with 61,050 birth-year matched control subjects without cancer diagnoses. Researchers performed multivariable logistic regression to elucidate how demographic, birth, and parental characteristics influence early malignancy.