Effects of early adulthood chronic sleep disruption on late life cognition, brain pathology, and microglial reactivity in the PS19 mouse model of tauopathy

This study examined the impact of chronic sleep disruption in early adulthood on the progression of tauopathy in a mouse model of Alzheimer's disease. Results showed that sleep-deprived mice unexpectedly performed better in spatial learning tasks, though they exhibited signs of sustained microglial proliferation.