EMJ·3 min read·hard
IBD and Reduced TGR5 Activation
J
Josh Lister
✦AI Summary
A recent study indicates that patients with inflammatory bowel disease (IBD) exhibit reduced activation of the TGR5 receptor due to altered bile acid profiles. This metabolic change, linked to gut microbiota composition, appears to impair immune tolerance and exacerbate inflammation.
INFLAMMATORY bowel disease ( IBD ) was associated with reduced activation of Takeda G protein-coupled receptor 5 (TGR5), with investigators reporting that altered bile acid profiles correlated with greater inflammatory activity.
sciencehealth
✦
Get the full story
Sign up for Headlinne to unlock AI insights, political bias analysis, and your personalized news feed.
Create free accountAlready have an account? Sign in