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Nature·4 min read·hard

Investigating the role of G-quadruplex-associated duplex stem loops in Trabectedin’s mechanism of action

S
Safarova, Alena
Investigating the role of G-quadruplex-associated duplex stem loops in Trabectedin’s mechanism of action
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This study investigates how the antitumor drug Trabectedin interacts with G-quadruplex (G4) DNA structures. Researchers found that while the drug can stabilize G4-duplex architectures, it maintains a stronger affinity for standard duplex DNA.

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