Lipopolysaccharide priming confers trained immunity and enhances antiviral defense against Sendai virus via STAT1/2 signaling

Researchers have discovered that priming the immune system with lipopolysaccharide (LPS) can induce 'trained immunity' in mice, providing enhanced protection against respiratory viruses like Sendai virus. This process involves the functional reprogramming of innate immune cells, which leads to a more efficient antiviral response through STAT1/2 signaling.