nature.com·3 min read·hard
Loss of LATS1 promotes immune evasion in colon cancer via YAP/TEAD-driven lactate metabolism reprogramming
Z
Zhang, Zhe
✦AI Summary
A study reveals that the loss of the LATS1 protein in colon cancer cells promotes immune evasion by reprogramming lactate metabolism via the YAP/TEAD pathway. Inhibiting the LDHA enzyme was found to reverse these immunosuppressive effects, suggesting a potential therapeutic target.
Scientific Reports ( 2026 ) Cite this article
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