Natural compound may fight rheumatoid arthritis at its source
A study published in Engineering suggests that a natural compound called obakulactone (OL) may effectively treat rheumatoid arthritis by targeting the ACOT1 enzyme. Experiments in rats showed that the compound reduced joint swelling and restored cartilage structure by balancing fatty acid metabolism.
A natural compound called obakulactone (OL) may offer a new way to treat rheumatoid arthritis (RA), according to a study published in Engineering . OL is a tetracyclic triterpenoid isolated from Phellodendri cortex . Researchers found that it reduced signs of arthritis by promoting the breakdown of acyl coenzyme A thioesterase 1 (ACOT1) through the ubiquitin‒proteasome pathway and by restoring the balance of unsaturated fatty acids.
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