genengnews.com·4 min read·hard
Protein Protects Against Tau Tangles, Synaptic Loss in Mouse Model of Tauopathy
S
Sophia Ktori
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Researchers at Sanford Burnham Prebys have identified that the protein SORLA helps protect the brain against tau tangles, which are associated with Alzheimer's disease. This discovery suggests that boosting SORLA levels could be a viable therapeutic strategy for treating neurodegenerative conditions.
Alzheimer’s disease (AD) and many other forms of neurodegeneration share a common culprit. In these diseases, tau proteins that normally stabilize neuronal microtubule filaments within nervous system networks instead form noxious knots and gradually disrupt the circuits they would otherwise preserve.
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