Scientists discover a protein that protects the brain from Alzheimer’s damage
Researchers at Sanford Burnham Prebys have identified a protein called SORLA that may help protect the brain from Alzheimer's-related tau tangles. This discovery suggests a potential new therapeutic pathway to prevent the cognitive decline associated with neurodegenerative diseases.
Alzheimer's disease and several other neurodegenerative disorders are linked to a damaging change in tau, a protein that normally helps support the internal structure of nerve cells. Under healthy conditions, tau stabilizes microtubules, the filament-like structures that help maintain neuronal shape and function. In disease, however, tau can twist into toxic tangles that interfere with the brain circuits it would normally help preserve.
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