Science Daily·3 min read·medium
Scientists may have found aging’s hidden trigger for brain disease
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Scientists have identified that the protein EPS8 accumulates with age and triggers signaling pathways that lead to toxic protein buildup in the brain. Reducing the activity of this protein in worm models helped prevent neurodegeneration, offering a potential target for treating diseases like ALS and Huntington's.
Aging is the strongest known risk factor for neurodegenerative diseases, yet researchers still do not fully understand which molecular changes associated with getting older cause these conditions to develop.
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