newswise.com·3 min read·hard
SKKU Researchers Develop World’s First Oral Microbiome-Based Nanomedicine to Supercharge Anti-Cancer Immunity
✦AI Summary
Researchers from SKKU and the University of Michigan have developed an oral nanomedicine that uses gut microbial metabolites to boost anti-cancer immunity. The treatment helps CD8+ T cells avoid metabolic exhaustion, significantly improving the efficacy of immunotherapy.
The gut microbial metabolite DHB promotes the formation of antigen-specific, stem-like CD8+ T cells by suppressing glycolysis and modulating the Akt-mTORC1-Myc pathway. Oral nano-emulsion formulation of DHB significantly improves its bioavailability, demonstrating potent anti-tumor efficacy when combined with immune checkpoint inhibitors.
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