SPOP Double-Donut Solves Cancer Mutation Mystery
Researchers at St. Jude Children's Research Hospital have discovered that the SPOP protein functions as a 'double-donut' structure when inactive and a filament when active. This structural balance is often disrupted by cancer-related mutations, providing a new target for potential therapeutic interventions.
(MEMPHIS, Tenn. - July 13, 2026) Mutations to the protein SPOP are widespread in cancer, yet many remain poorly understood. To address this gap, St. Jude Children's Research Hospital scientists obtained structures of SPOP in both the presence and absence of these mutations. Their work captured the fine balance between active and inactive states of SPOP, showing how its activity is regulated and revealing that a key subset of cancer mutations disrupt this balance, providing the missing clue for their roles in disease. The study was published today in Molecular Cell.
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