What does the new research on Vitamin B12-based therapy for brain cancer reveal?
Researchers have developed a modified vitamin B12 analogue called NO-Cbl that can cross the blood-brain barrier to target glioblastoma cells. This preclinical study uses the molecule to deliver nitric oxide directly to tumors, offering a potential new pathway for brain cancer treatment.
Despite decades of research, Glioblastoma multiforme (GBM) still remains one of the deadliest types of brain cancers . While treatments including surgery, radiotherapy, and chemotherapy exist and have improved over time, the outcomes for patients remain generally poor. One of the major obstacles to treatment lies in the brain’s natural protection – the blood-brain barrier (BBB) that restricts the passage of anticancer drugs into the tumour.
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